CANCER CELL SURVIVAL FOLLOWING DNA DAMAGE-MEDIATED PREMATURE SENESCENCE IS REGULATED BY MAMMALIAN TARGET OF RAPAMYCIN (mTOR)- DEPENDENT INHIBITION OF SIRTUIN
نویسندگان
چکیده
Back, Jung Ho, Hamid Reza Rezvani, Yucui Zhu, Véronique Guyonnet-Duperat, Mohammad Athar, Desiree Ratner, and Arianna L. Kim From Departments of Dermatology, Columbia University Medical Center, New York, NY 10032; Inserm 1035, Bordeaux, F-33076, France; Université Bordeaux Segalen, Bordeaux, F-33076, France; SFR TransBioMed, Plateforme de vectorologie, Université Bordeaux Segalen, Bordeaux, F33076, France; University of Alabama at Birmingham, Birmingham, AL 35205, USA Running head: mTOR inhibits SIRT1 to promote cancer cell survival Address correspondence to: Arianna L. Kim, Ph.D. 1150 St. Nicholas St. 318A, New York, NY 10032. Fax: 212-851-4540; E-mail:[email protected]
منابع مشابه
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.
DNA-damaging agents can induce premature senescence in cancer cells, which contributes to the static effects of cancer. However, senescent cancer cells may re-enter the cell cycle and lead to tumor relapse. Understanding the mechanisms that control the viability of senescent cells may be helpful in eliminating these cells before they can regrow. Treating human squamous cell carcinoma (SCC) cell...
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